Beautiful, wealthy, young Izumi has found fame starring in softcore sex thrillers, but her career is at stake when she develops a flesh-rotting skin disease. She hatches a radical treatment plan -- she'll have a daughter rand perform a brain transplant with a home-made machine that resembles a big iron bug.  Many years later, the plan works perfectly (and features an ocean's worth of blood and gore, accompanied by satisfying squishy noises), but the kid, Sakura (who's now really the mom) has acquired a handsome, horny piano teacher who may-or-may-not-be dumping his pregnant, jealous wife.  Between the wife's attempts to have Sakura/Izumi committed to a mental institution, the reappearance of the facial fungus, and the mysterious disappearance of her old body, life as a medical oddity isn't quite what Izumi-as-Sakura had hoped.  And it's probably not being helped in a major way by all those self-administered injections....

Improbable plot twists occur every few minutes, and the end is a paean to the mother/daughter bond, vis-à-vis the subjective nature of sanity that would have done both Carrie White and R.D. Lang proud.

Plus, it's awfully funny.